John F Canales, MD, FACC

John F Canales, MD, FACC

Growing up listening to his father, an insurance agent, tell the stories of his clients had a profound effect on the kind of physician Dr. John Canales would become. “I like hearing my patients’ stories. I think it makes me a better interventionalist because I understand where they’re coming from and how my treatments may affect their lives,” says Dr. Canales.

Dr. Canales was trained at some of the country’s most prestigious institutions. He completed medical school at Washington University in St. Louis and his internship and residency at the University of Texas Southwestern in Dallas. Dr. Canales then went to the Texas Heart Institute in Houston for his general and interventional cardiology fellowships. While there, he completed training in the non-surgical treatment of complex coronary and peripheral vascular disease.

Dr. Canales was also very active academically at the Texas Heart Institute. He investigated the role of using a patient’s own stem cells to regenerate damaged heart muscle and to rebuild arteries in the legs with severe blockages. His academic excellence, interventional skill, and compassionate care resulted in the honor of being named Chief General Cardiology Fellow and Chief Interventional Fellow at the Texas Heart Institute.

After training, Dr. Canales spent two years in New Braunfels practicing general and interventional cardiology. During his short time there, he became the Director of the Catheterization Laboratory at Christus Santa Rosa Hospital in New Braunfels and Chairman of the Limb Salvage Committee, a group dedicated to caring for patients with severe peripheral arterial disease.

But San Antonio was his home growing up and many of his family and friends were still there. So, Dr. Canales decided to join the Cardiology Clinic of San Antonio in August, 2013.

His interests and skills include treating complex coronary interventions and peripheral vascular disease. He has taken a special interest in patients with critical limb ischemia, renal arterial disease, lower extremity arterial disease, and venous disease. Dr. Canales is specially trained to use drug-eluting stents and balloons, cutting-edge atherectomy devices, and fractional flow reserve and intravascular ultrasound to guide coronary and peripheral interventions.

Dr. Canales is board certified in interventional cardiology, cardiolovascular diseases and nuclear cardiology. He practices out of Cardiology Clinic’s Northeast office. 

Publications/Book Chapters

  1. Canales JFWide Complex Tachycardia. In:  Katz J, Patel C, Aslam K, eds.  Parkland Manual of Inpatient Medicine: An Evidence Based Approach.  Philadelphia, PA: F.A. Davis (2005).
  1. Dorfman T, Canales JF, McGuire DK, Farukhi I, Erdman WA, Peshock A.   Case Report:  Cardiac Sarcoidosis Presenting as an Acute Coronary Syndrome.  Cardiology in Review 2005; Sept-Oct; 13(5): 256-259.
  1. Perin EC, Silva GV, Fernandes MR, Munger T, Pandey A, Sehra R, Talcott M, Bichard CJ, Creed J, Wong J, Oliveira E, Zheng Y, Canales J, et al.  First experience with remote left ventricular mapping and transendocardial cell injection with a novel integrated magnetic navigation-guided electromechanical mapping system. EuroIntervention 2007; 3: 142-148.
  1. Canales JF, Ferguson JJ.  Low Molecular Weight Heparins:  Mechanisms, Trials and Role in Contemporary Interventional Medicine.  Am J Cardiovascular Drugs 2008; 8(1): 15-25.
  1. Silva GS, Canales JF, Perin EC.  Cell Based Therapy for Ischemic Heart Disease. In:  Tremmel J, editor in chief. Science Innovation Synergy 2007 Yearbook.  Online at
  1. Goel N, Canales J, Ferguson JJ.  Management of Antiplatelet Therapy for Non-cardiac Surgery. In:  Antman E, Wiviott SD, eds.  American Heart Association Book Series: Antiplatelet Therapy in Ischemic Heart Disease.  Pages 251-264.  Blackwell Publishing Co. 2008.
  1. Fernandes MR, Silva GS, Zheng Y, Oliveira EM, Cardoso CO, Canales J, et al.  Validation of New QwikStar Catheter for Electromechanical Mapping with NOGA XP System.  Texas Heart Institute Journal 2008; 35: 240-9.
  1. Canales JF, Ferguson JJ.  Of hammers, nails, and our ever expanding box of tools.  Rev Bras Cardiol Invas. 2008; 1 6(2): 131-133.
  1. Bonaca M, Steg P, Feldman L, Canales JF, Ferguson JJ, Wallentin L, Callif RM, Harrington RA, Giugliano RP.  Antithrombotics in Acute Coronary Syndromes.  JACC 2009; 54(11):  969-84.
  1. Silva G, Fernandes M, Madonna R, Clubb F, Olivera E, Jimenez-Quevedo P, Branco R, Lopez J, Angeli F, Sanz R, Vaughn W, Zheng Y, Baimbridge F, Canales J, et al.  Comparative healing response after sirolimus and paclitaxel eluting stent implantation in a pig model of restenosis.  Cath and Cardiovasc Intervent 2009; 73(6): 801-8.
  2. Canales JF, Krajcer Z.  Intravascular Ultrasound Guidance In Treating May-Thurner Syndrome.  THI Journal 2010; 37(4): 498-9.
  3. Canales JF, Cardenas JC, Dougherty K, Krajcer Z.  Single Center Experience with Percutaneous Endovascular Repair of Superior Vena Cava Syndrome.  Cath and Cardiovasc Intervent 2011; 77(5): 733-739.
  4. Perin EC, Silva GS, Gahremanpour A, Canales J, Zheng Y, et al.  A Randomized, Controlled Study of Autologous Therapy with Bone Marrow Derived Aldehyde Dehydrogenase Bright Cells in Patients with Critical Limb Ischemia.  Cath and Cardiovasc Intervent 2011; Dec 1; 78(7):  1060-7.
  5. Perin EC, Silva GV, Fernandes MR, Henry T, Moore W, Coulter S, Herlihy P, Cheong B, Flamm S, Shaw S, Westbrook L, Smith D, Zheng Y, Cardoso C, Canales J, et al.  FOCUS-HF: A Randomized Study of Transendocardial Injection of Autologous Bone Marrow Mononuclear Cells and Cell Function Analysis in Ischemic Heart Failure Patients.  Am J Heart J.  2011 Jun; 161(6):  1078-87.
  6. Perin EC, Silva GS, Zheng Y, Gahremanpour A, Canales J, et al.  Randomized, double-blind pilot study of transendocardial injection of autologous aldehyde dehydrogenase-bright stem cells in patients with ischemic heart failure.  Am Heart J.  2012 Mar; 163(3):  415-21.
  7. Fernandes MR, Fish RD, Canales J, Aliota J, Silva GS, et al.  Restoration of microcirculatory patency after myocardial infarction: results of current coronary interventional strategies and techniques.  Texas Heart In J.  2012; 39(3):  342-50.

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Medical Education & Training

Medical School: Washington University School of Medicine, St. Louis, MO
Residency: University of Texas Southwestern, Dallas, TX
Fellowship: Interventional Cardiology: Texas Heart Institute and Baylor College of Medicine, Houston, TX
Cardiology: Texas Heart Institute and Baylor College of Medicine, Houston, TX
Cardiology Research: Stem Cell Center at Texas Heart Institute, Houston, TX
Specialty Board Certifications: Cardiovascular Diseases
Interventional Cardiology
Nuclear Cardiology


American College of Cardiology
American Heart Association

Procedures and Conditions


  • Preventative and Therapeutic Adult Cardiovascular Medicine
  • Exercise and Pharmacologic Stress Tests (Nuclear and Echocardiographic)
  • Transesophageal Echocardiography
  • Peripheral Arterial Disease Management
  • Carotid, Abdominal and Peripheral Arterial Image Interpretation
  • Advanced Coronary and Peripheral Vascular Research


  • Cardiac Catheterization
  • Percutaneous Coronary Artery Interventions
  • Complex Coronary Interventions (Rotablator Atherectomy)
  • Peripheral Artery Intervention with/without Atherectomy
  • Radial Access Interventions
  • Advanced Arterial Access Techniques: Brachial artery, Popliteal Artery, Pedal Arteries
  • Antegrade and Retrograde Common Femoral Access Techniques
  • Chronic Total Occlusion of the Coronary and Peripheral Arteries
  • Critical Limb Ischemia
  • Limb Salvage
  • Renal Artery Interventions




English, Spanish

John F Canales, MD, FACC


Cardiovascular Diseases
See more Cardiovascular Diseases Physicians
Interventional Cardiology
See more Interventional Cardiology Physicians

Sub Specialty

Peripheral Vascular Interventions
See more Peripheral Vascular Interventions Physicians

John F Canales, MD, FACC


(210) 614-5400

Office Locations

Cardiology Clinic of San Antonio - Stone Oak
255 E. Sonterra Blvd. #150
San Antonio, TX 78258
Phone: (210) 490-6000
Fax: (210) 490-4658
Cardiology Clinic of San Antonio - Northeast

12709 Toepperwein Rd. #306
San Antonio, TX 78233
Phone: (210) 967-0096
Fax: (210) 967-0383
Cardiology Clinic of San Antonio - Uvalde

Uvalde Medical & Surgical Associates
1195 Garner Field Rd. Uvalde, TX
Phone: 78801
Fax: (830) 278-3086
(830) 278-8873


South Texas Vascular Health Center

South Texas Vascular Health Center
4411 Medical Dr.
Suite 300
San Antonio, TX 78229
Phone: (210) 575-2PAD [2723]